mRNA, technology, machine learning and validation details
What exactly is mRNA, how is it different from RNA and DNA, and how can it be used in diagnostic testing? How does machine learning come into play? How does Inflammatix develop its laboratory tests, and what do NPV, PPV, AUROC, sensitivity, and specificity tell us about the reliability of a laboratory test? How are laboratory tests validated, and how do we know if the tests provide the information they say they provide? Find that information here, as we gather informative and educational content.
DYSREGULATION—Infection can trigger the immune gene response to go haywire in multiple ways.
What is Sepsis?
Sepsis is a dysregulated immune response that can be triggered by any acute infection. It can lead to tissue damage, organ failure, and worse. With the highest hospital mortality of any diagnosis, sepsis accounts for nearly half of in-hospital deaths.
Sepsis kills over 250,000 people in the US alone each year, and more than 5 million people worldwide – more than breast cancer, prostate cancer, and HIV/AIDS combined. Contrary to widespread belief, bacteria is often not found in the blood of patients with acute infections or sepsis. Fewer than 10% of patients hospitalized for acute infections and only about half of patients with septic shock are bacteremic.