HostDx Tests 2017-10-28T09:08:02+00:00

Groundbreaking HostDx Tests

The Inflammatix HostDx diagnostics are powered by ‘reading’ the immune system instead of looking for a bug. Our immune system has developed targeted responses to different types of infections and other diseases over millions of years of evolution.  We are initially launching HostDx Sepsis and HostDx Fever for better acute infection and sepsis diagnosis based on patent-pending biomarkers exclusively licensed from Stanford University.

HostDx Sepsis

Shooting for the holy grail:  Identify the presence, type and severity of an acute infection.

Tailored for emergency rooms. urgent care clinics and inpatient use to diagnose (or rule out) acute infection and sepsis in multiple clinical scenarios:

  • First presentation in the ED or urgent care clinic
  • Identifying infections in traumatic injuries
  • Neonate and ICU patient monitoring
HostDx-sepsis
HostDx-sepsis-diagnostic-tree

Validation study results for the HostDx Sepsis test:  

IndicationSensitivitySpecificity
Bacterial Infection94%60%
Viral Infection53%91%
30-day mortality (sepsis)95%64%
HostDx SepsisNon-Flu SeasonFlu Season
Infection TypeEstimated PrevalenceNPVPPVEstimated PrevalenceNPVPPV
Bacterial Infection30%96%50%15%99%30%
Viral Infection50%66%86%75%40%95%
Sepsis25%98%47%20%98%40%

Sweeney TE, Wong HR, Khatri P. “Robust classification of bacterial and viral infections via integrated host gene expression diagnostics.” Science Translational Medicine, Jul 6 2016.
Sweeney TE, et al. “Validation of the Sepsis MetaScore for diagnosis of neonatal sepsis.” J Ped Infect Dis Soc. Apr 13, 2017.

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HostDx Fever

Soon, we’ll answer your simple question: Is my infection bacterial or viral?

Ideal for outpatient clinics and urgent care centers

Safely and confidently avoid prescribing antibiotics on negative results (multiple validation studies indicate that the HostDx Fever test can achieve a greater than 95% negative predictive value for bacterial infection )

HostDx-fever

Validation study results for the HostDx Fever test

(bacterial infection as the “case” and viral infection as the “control”):

IndicationSensitivitySpecificity
Bacterial Infection96%76%
HostDx FeverNon-Flu SeasonFlu Season
Infection TypeEstimated PrevalenceNPVPPVEstimated PrevalenceNPVPPV
Bacterial Infection35% Bacterial / 65% Viral97%69%20% Bacterial / 80% Viral99%50%

Sweeney TE, Wong HR, Khatri P. “Robust classification of bacterial and viral infections via integrated host gene expression diagnostics.” Science Translational Medicine, Jul 6 2016.

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Where Are We Now?

We are in the process of fitting our HostDx assays onto novel diagnostic instruments with ideal product-market fit. Then, we will execute clinical studies required for regulatory clearance across the globe.

Scour appropriate cohorts in public and private datasets (raw gene expression and clinical data) to identify optimal genes and develop algorithms

Apply locked algorithms on multiple independent (blinded) public and private data sets (also with raw gene expression and clinical data)

Develop assays (wet lab) based on locked set of genes and algorithms and work with instrument partners to finalize assay

Validate assay locked on partners’ instruments in independent (blinded) and representative clinical studies

Attain regulatory clearance (e.g. CE, 510K) and launch HostDx tests to clinics and hospitals globally

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